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WATER DISPERSIBLE PLANT STEROLS TO LOWER CHOLESTEROL

High level in blood cholesterol is the first risk factor for coronary heart disease. Studies have shown that a 10% decrease in blood cholesterol level reduces cardiovascular disease risk between 19% to 54% depending on a person age. And a consumption of 1,5 g to 3 g of plant sterols (or phytosterols) per day lowers LDL Cholesterol by 8% to 15%.

LIPOPHYTOL Properties

• Easy to use: water dispersible powder

• Fat free ingredient: no additional esterified fatty acid

• No fat oxidation during shelf-life of finished product

• Efficiency on lowering blood cholesterol level and atherosclerosis is demonstrated

• Novel food approval from the EU

• Registrated brand.

Applications

Free phytosterols are insoluble in water and in oil therefore impossible to use in foods and in beverages without a delivery system. Thanks to its expertise in microencapsulation, Lipofoods overcame the problem by coating the microparticles of phytosterols, providing a water-dispersible way of introducing phytosterols into the diet. Lipophytol lowers cholesterol absorption and allows the use of sterols in 100% fat free foods and beverages, avoiding the consumption of additional fat. Lipophytol is available in powder form with 70% plant sterols and in liquid form with 25% plant sterols. It can be used in dairy products, fruit preparations, yellow fat spreads, soy drinks, food supplements, etc...

Efficacy Test

VLDL and LDL (“bad”) cholesterol levels.

In a trial with groups of 7 mice fed with 2% plant sterols in form of Lipophytol and 2% plant sterols in form of esters, bad cholesterol (LDL and VLDL) decreased dramatically in both groups compared with the control group.

Atherosclerotic lesions area.

After 8 weeks mice were sacrified and atherosclerotic areas of the aorta artery were quantified. The atherosclerotic area in animal fed with Lipophytol was 54% lower (statistically significant p< 0.05) than in the control group.

Publications

More data about this study can be found in the following publications:

Calpe-Berdiel L, Escolà-Gil JC & Blanco-Vaca F. Phytosterol-mediated inhibition of intestinal cholesterol absorption is independent of ATP-binding cassette transporter A1. British Journal of Nutrition (2006), 95, 1-6.
Calpe-Berdiel L, Escolà-Gil JC, Ribas V, Navarro-Sastre A, Garcés-Garcés J & Blanco-Vaca F. Changes in intestinal and liver global gene expression in response to a phytosterol-enriched diet. Atherosclerosis (2005), 181, 75-85.

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